Biomarkers of Inflammation and Endothelial Activation in Vertically HIV-1 Infected Children
نویسنده
چکیده
Background: Chronic inflammation, which may predispose to cardiovascular disease (CVD), persists in HIV-1 infected adults despite sustained viral suppression (SVS). There are limited data on chronic inflammation and endothelial activation (EA) in vertically infected children. This study examines markers of inflammation and EA in virally suppressed, vertically HIV infected children enrolled in the Canadian EPIC4 cohort.
منابع مشابه
Inflammatory and Neuronal Biomarkers Associated With Retinal Thinning in Pediatric HIV.
Purpose The pathophysiology of neuroretinal thinning in children with human immunodeficiency virus (HIV) is poorly understood. The current study aimed to assess whether neuroretinal thinning in clinically stable perinatally HIV-infected children was associated with biomarkers of immune activation, inflammation, and neuronal damage. Methods Inflammation-associated and neuronal damage markers w...
متن کاملRelationship between inflammatory markers, endothelial activation markers, and carotid intima-media thickness in HIV-infected patients receiving antiretroviral therapy.
BACKGROUND Human immunodeficiency virus (HIV)-infected patients are at increased risk of cardiovascular disease, which may be related to chronic inflammation and endothelial dysfunction despite virological control with antiretroviral therapy. The relationship between carotid intima-media thickness (IMT), a surrogate marker for cardiovascular disease, proinflammatory cytokines, and endothelial a...
متن کاملSystemic Immune Activation Profiles of HIV-1 Subtype C-Infected Children and Their Mothers
Little is known about immune activation profiles of children infected with HIV-1 subtype C. The current study compared levels of selected circulating biomarkers of immune activation in HIV-1 subtype C-infected untreated mothers and their children with those of healthy controls. Multiplex bead array, ELISA, and immunonephelometric procedures were used to measure soluble CD14 (sCD14), beta-2 micr...
متن کاملHIV infection, antiretroviral therapy, and measures of endothelial function, inflammation, metabolism, and oxidative stress
BACKGROUND HIV-infected patients have an increased risk of cardiovascular disease (CVD). Impaired endothelial function is an early risk factor for CVD in the general population. It is presumed that HIV infection is associated with impaired endothelial function, but results have been inconsistent. OBJECTIVES Our objectives were to determine the relationships between HIV infection, virologic su...
متن کاملReduced sTWEAK and Increased sCD163 Levels in HIV-Infected Patients: Modulation by Antiretroviral Treatment, HIV Replication and HCV Co-Infection
BACKGROUND Patients infected with the human immunodeficiency virus (HIV) have an increased risk of cardiovascular disease due to increased inflammation and persistent immune activation. CD163 is a macrophage scavenger receptor that is involved in monocyte-macrophage activation in HIV-infected patients. CD163 interacts with TWEAK, a member of the TNF superfamily. Circulating levels of sTWEAK and...
متن کامل